CLK2 Condensates Reorganize Nuclear Speckles and Induce Intron Retention
CLK2 Condensates Reorganize Nuclear Speckles and Induce Intron Retention
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Author / Creator
Wang, Bing , Li, Jing , Song, Yanyang , Qin, Xuhui , Lu, Xia , Huang, Wei , Peng, Chentai , Wei, Jinxia , Huang, Donghui and Wang, Wei
Publisher
Germany: John Wiley & Sons, Inc
Journal title
Language
English
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Publication information
Publisher
Germany: John Wiley & Sons, Inc
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Scope and Contents
Contents
Intron retention (IR) constitutes a less explored form of alternative splicing, wherein introns are retained within mature mRNA transcripts. This investigation demonstrates that the cell division cycle (CDC)‐like kinase 2 (CLK2) undergoes liquid–liquid phase separation (LLPS) within nuclear speckles in response to heat shock (HS). The formation of...
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Full title
CLK2 Condensates Reorganize Nuclear Speckles and Induce Intron Retention
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_0bc8673f05a645b0abf454b8a44d5e5f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0bc8673f05a645b0abf454b8a44d5e5f
Other Identifiers
ISSN
2198-3844
E-ISSN
2198-3844
DOI
10.1002/advs.202309588
