An Efficient Synthesis of 2-CF3-3-Benzylindoles
An Efficient Synthesis of 2-CF3-3-Benzylindoles
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Basel: MDPI AG
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Language
English
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Basel: MDPI AG
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The reaction of α-CF3-β-(2-nitroaryl) enamines with benzaldehydes afforded effectively α,β-diaryl-CF3-enones having nitro group. Subsequent reduction of nitro group by NH4HCO2-Pd/C system initiated intramolecular cyclization to give 2-CF3-3-benzylindoles. Target products can be prepared in up to quantitative yields. Broad synthetic scope of the rea...
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Full title
An Efficient Synthesis of 2-CF3-3-Benzylindoles
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TN_cdi_doaj_primary_oai_doaj_org_article_0bd7c02548c9445a9eeda508cd9015ca
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0bd7c02548c9445a9eeda508cd9015ca
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ISSN
1420-3049
E-ISSN
1420-3049
DOI
10.3390/molecules26165084
