Anti-VEGFR2 F(ab′)2 drug conjugate promotes renal accumulation and glomerular repair in diabetic nep...
Anti-VEGFR2 F(ab′)2 drug conjugate promotes renal accumulation and glomerular repair in diabetic nephropathy
About this item
Full title
Author / Creator
Liu, Di , Song, Yanling , Chen, Hui , You, Yuchan , Zhu, Luwen , Zhang, Jucong , Xu, Xinyi , Hu, Jiahao , Huang, Xiajie , Wu, Xiaochuan , Xu, Xiaoling , Jiang, Saiping and Du, Yongzhong
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Poor renal distribution of antibody-based drugs is the key factor contributing to low treatment efficiency for renal diseases and side effects. Here, we prepare F(ab′)
2
fragmented vascular endothelial growth factor receptor 2 antibody (anti-VEGFR2 (F(ab′)
2
) to block VEGFR2 overactivation in diabetic nephropathy (DN). We find that the...
Alternative Titles
Full title
Anti-VEGFR2 F(ab′)2 drug conjugate promotes renal accumulation and glomerular repair in diabetic nephropathy
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_0be0f897c36d40419a5c775825212f5e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0be0f897c36d40419a5c775825212f5e
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-43847-2
