H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential...
H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis
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Author / Creator
Harutyunyan, Ashot S. , Krug, Brian , Chen, Haifen , Papillon-Cavanagh, Simon , Zeinieh, Michele , De Jay, Nicolas , Deshmukh, Shriya , Chen, Carol C. L. , Belle, Jad , Mikael, Leonie G. , Marchione, Dylan M. , Li, Rui , Nikbakht, Hamid , Hu, Bo , Cagnone, Gael , Cheung, Warren A. , Mohammadnia, Abdulshakour , Bechet, Denise , Faury, Damien , McConechy, Melissa K , Pathania, Manav , Jain, Siddhant U. , Ellezam, Benjamin , Weil, Alexander G. , Montpetit, Alexandre , Salomoni, Paolo , Pastinen, Tomi , Lu, Chao , Lewis, Peter W. , Garcia, Benjamin A. , Kleinman, Claudia L. , Jabado, Nada and Majewski, Jacek
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Contents
Lys-27-Met mutations in histone 3 genes (H3K27M) characterize a subgroup of deadly gliomas and decrease genome-wide H3K27 trimethylation. Here we use primary H3K27M tumor lines and isogenic CRISPR-edited controls to assess H3K27M effects in vitro and in vivo. We find that whereas H3K27me3 and H3K27me2 are normally deposited by PRC2 across broad reg...
Alternative Titles
Full title
H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis
Authors, Artists and Contributors
Author / Creator
Krug, Brian
Chen, Haifen
Papillon-Cavanagh, Simon
Zeinieh, Michele
De Jay, Nicolas
Deshmukh, Shriya
Chen, Carol C. L.
Belle, Jad
Mikael, Leonie G.
Marchione, Dylan M.
Li, Rui
Nikbakht, Hamid
Hu, Bo
Cagnone, Gael
Cheung, Warren A.
Mohammadnia, Abdulshakour
Bechet, Denise
Faury, Damien
McConechy, Melissa K
Pathania, Manav
Jain, Siddhant U.
Ellezam, Benjamin
Weil, Alexander G.
Montpetit, Alexandre
Salomoni, Paolo
Pastinen, Tomi
Lu, Chao
Lewis, Peter W.
Garcia, Benjamin A.
Kleinman, Claudia L.
Jabado, Nada
Majewski, Jacek
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_0beae741fed94f66b31dab929cbfe1ba
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0beae741fed94f66b31dab929cbfe1ba
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-09140-x
