Protein disulfide isomerase cleaves allosteric disulfides in histidine-rich glycoprotein to regulate...
Protein disulfide isomerase cleaves allosteric disulfides in histidine-rich glycoprotein to regulate thrombosis
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Author / Creator
Lv, Keyu , Chen, Shuai , Xu, Xulin , Chiu, Joyce , Wang, Haoqing J. , Han, Yunyun , Yang, Xiaodan , Bowley, Sheryl R. , Wang, Hao , Tang, Zhaoming , Tang, Ning , Yang, Aizhen , Yang, Shuofei , Wang, Jinyu , Jin, Si , Wu, Yi , Schmaier, Alvin H. , Ju, Lining A. , Hogg, Philip J. and Fang, Chao
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The essence of difference between hemostasis and thrombosis is that the clotting reaction is a highly fine-tuned process. Vascular protein disulfide isomerase (PDI) represents a critical mechanism regulating the functions of hemostatic proteins. Herein we show that histidine-rich glycoprotein (HRG) is a substrate of PDI. Reduction of HRG by PDI enh...
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Full title
Protein disulfide isomerase cleaves allosteric disulfides in histidine-rich glycoprotein to regulate thrombosis
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TN_cdi_doaj_primary_oai_doaj_org_article_0c086c6b87a448a69a22678f0a155a5d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0c086c6b87a448a69a22678f0a155a5d
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-47493-0
