Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s dise...
Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s disease
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London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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The relationship between amyloid-β (Aβ) species and tau pathology in Alzheimer’s disease (AD) is not fully understood. Here, we provide direct evidence that Aβ42/40 ratio, not total Aβ level, plays a critical role in inducing neurofibrillary tangles (NTFs) in human neurons. Using 3D-differentiated clonal human neural progenitor cells (hNPCs) expres...
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Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s disease
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TN_cdi_doaj_primary_oai_doaj_org_article_0c1c3533dcca447694dd527474cb0871
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0c1c3533dcca447694dd527474cb0871
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-15120-3
