A robust high-throughput screening system to assess bacterial tyrosine ammonia lyase activity in the...
A robust high-throughput screening system to assess bacterial tyrosine ammonia lyase activity in the context of tyrosine inherited metabolic disorders
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Inborn errors of tyrosine metabolism result in patient’s inability to degrade tyrosine. Current treatment consists of a phenylalanine and tyrosine restricted diet and nitisinone, causing a block in the tyrosine degradation pathway. However, tyrosine levels will increase, leading to acquired hypertyrosinemia, implying the need for an add-on treatmen...
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A robust high-throughput screening system to assess bacterial tyrosine ammonia lyase activity in the context of tyrosine inherited metabolic disorders
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TN_cdi_doaj_primary_oai_doaj_org_article_0c449b63f7e24fcb8b231baea9f8011a
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0c449b63f7e24fcb8b231baea9f8011a
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-024-72360-9