Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK
Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
No effective targeted therapies exist for cancers with somatic
KRAS
mutations. Here we develop a synthetic lethal chemical screen in isogenic
KRAS
-mutant and wild-type cells to identify clinical drug pairs. Our results show that dual inhibition of polo-like kinase 1 and RhoA/Rho kinase (ROCK) leads to the synergistic effects in
KRAS...
Alternative Titles
Full title
Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK
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TN_cdi_doaj_primary_oai_doaj_org_article_0c74c6b0573c4f9f816fe66db2394a14
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0c74c6b0573c4f9f816fe66db2394a14
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms11363
