Impaired TIGIT expression on B cells drives circulating follicular helper T cell expansion in multip...
Impaired TIGIT expression on B cells drives circulating follicular helper T cell expansion in multiple sclerosis
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United States: American Society for Clinical Investigation
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Language
English
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Publisher
United States: American Society for Clinical Investigation
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B cell depletion in patients with relapsing-remitting multiple sclerosis (RRMS) markedly prevents new MRI-detected lesions and disease activity, suggesting the hypothesis that altered B cell function leads to the activation of T cells driving disease pathogenesis. Here, we performed comprehensive analyses of CD40 ligand- (CD40L-) and IL-21-stimulat...
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Full title
Impaired TIGIT expression on B cells drives circulating follicular helper T cell expansion in multiple sclerosis
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TN_cdi_doaj_primary_oai_doaj_org_article_0c9d8420a9fe4098b16d60ae27757205
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0c9d8420a9fe4098b16d60ae27757205
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ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI156254
