Optimized metrics for orthogonal combinatorial CRISPR screens
Optimized metrics for orthogonal combinatorial CRISPR screens
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Publisher
London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
CRISPR-based gene perturbation enables unbiased investigations of single and combinatorial genotype-to-phenotype associations. In light of efforts to map combinatorial gene dependencies at scale, choosing an efficient and robust CRISPR-associated (Cas) nuclease is of utmost importance. Even though SpCas9 and AsCas12a are widely used for single, com...
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Optimized metrics for orthogonal combinatorial CRISPR screens
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TN_cdi_doaj_primary_oai_doaj_org_article_0cb5e2ca754b4bf893f7228f118c97be
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0cb5e2ca754b4bf893f7228f118c97be
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-023-34597-8
