SIKs control osteocyte responses to parathyroid hormone
SIKs control osteocyte responses to parathyroid hormone
About this item
Full title
Author / Creator
Wein, Marc N. , Liang, Yanke , Goransson, Olga , Sundberg, Thomas B. , Wang, Jinhua , Williams, Elizabeth A. , O’Meara, Maureen J. , Govea, Nicolas , Beqo, Belinda , Nishimori, Shigeki , Nagano, Kenichi , Brooks, Daniel J. , Martins, Janaina S. , Corbin, Braden , Anselmo, Anthony , Sadreyev, Ruslan , Wu, Joy Y. , Sakamoto, Kei , Foretz, Marc , Xavier, Ramnik J. , Baron, Roland , Bouxsein, Mary L. , Gardella, Thomas J. , Divieti-Pajevic, Paola , Gray, Nathanael S. , Kronenberg, Henry M. , Faculty of Medicine , Medicinska fakulteten , Strategiska forskningsområden (SFO) , Department of Experimental Medical Science , Strategic research areas (SRA) , Lunds universitet , Profilområden och andra starka forskningsmiljöer , Lund University , EXODIAB: Excellence of Diabetes Research in Sweden , Protein Phosphorylation , Proteinfosforylering , Institutionen för experimentell medicinsk vetenskap and Profile areas and other strong research environments
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Parathyroid hormone (PTH) activates receptors on osteocytes to orchestrate bone formation and resorption. Here we show that PTH inhibition of
SOST
(sclerostin), a WNT antagonist, requires HDAC4 and HDAC5, whereas PTH stimulation of RANKL, a stimulator of bone resorption, requires CRTC2. Salt inducible kinases (SIKs) control subcellular locali...
Alternative Titles
Full title
SIKs control osteocyte responses to parathyroid hormone
Authors, Artists and Contributors
Author / Creator
Liang, Yanke
Goransson, Olga
Sundberg, Thomas B.
Wang, Jinhua
Williams, Elizabeth A.
O’Meara, Maureen J.
Govea, Nicolas
Beqo, Belinda
Nishimori, Shigeki
Nagano, Kenichi
Brooks, Daniel J.
Martins, Janaina S.
Corbin, Braden
Anselmo, Anthony
Sadreyev, Ruslan
Wu, Joy Y.
Sakamoto, Kei
Foretz, Marc
Xavier, Ramnik J.
Baron, Roland
Bouxsein, Mary L.
Gardella, Thomas J.
Divieti-Pajevic, Paola
Gray, Nathanael S.
Kronenberg, Henry M.
Faculty of Medicine
Medicinska fakulteten
Strategiska forskningsområden (SFO)
Department of Experimental Medical Science
Strategic research areas (SRA)
Lunds universitet
Profilområden och andra starka forskningsmiljöer
Lund University
EXODIAB: Excellence of Diabetes Research in Sweden
Protein Phosphorylation
Proteinfosforylering
Institutionen för experimentell medicinsk vetenskap
Profile areas and other strong research environments
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_0cde2d55d46f474080f0807c4fb646c2
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0cde2d55d46f474080f0807c4fb646c2
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms13176
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