MRNIP condensates promote DNA double-strand break sensing and end resection
MRNIP condensates promote DNA double-strand break sensing and end resection
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The rapid recognition of DNA double-strand breaks (DSBs) by the MRE11/RAD50/NBS1 (MRN) complex is critical for the initiation of DNA damage response and DSB end resection. Here, we show that MRN complex interacting protein (MRNIP) forms liquid-like condensates to promote homologous recombination-mediated DSB repair. The intrinsically disordered reg...
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MRNIP condensates promote DNA double-strand break sensing and end resection
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TN_cdi_doaj_primary_oai_doaj_org_article_0d2d630dc0a747b8807be46604e76da1
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0d2d630dc0a747b8807be46604e76da1
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-30303-w
