In vivo generation of human CD19‐CAR T cells results in B‐cell depletion and signs of cytokine relea...
In vivo generation of human CD19‐CAR T cells results in B‐cell depletion and signs of cytokine release syndrome
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Chimeric antigen receptor (CAR) T cells brought substantial benefit to patients with B‐cell malignancies. Notwithstanding, CAR T‐cell manufacturing requires complex procedures impeding the broad supply chain. Here, we provide evidence that human CD19‐CAR T cells can be generated directly
in vivo
using the lentiviral vector CD8‐LV specifically...
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Full title
In vivo generation of human CD19‐CAR T cells results in B‐cell depletion and signs of cytokine release syndrome
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TN_cdi_doaj_primary_oai_doaj_org_article_0d3a5818f8be4f4293451029dc69af29
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0d3a5818f8be4f4293451029dc69af29
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ISSN
1757-4676
E-ISSN
1757-4684
DOI
10.15252/emmm.201809158
