Diverse roles of the metal binding domains and transport mechanism of copper transporting P-type ATP...
Diverse roles of the metal binding domains and transport mechanism of copper transporting P-type ATPases
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Author / Creator
Guo, Zongxin , Orädd, Fredrik , Bågenholm, Viktoria , Grønberg, Christina , Ma, Jian Feng , Ott, Peter , Wang, Yong , Andersson, Magnus , Pedersen, Per Amstrup , Wang, Kaituo , Gourdon, Pontus , Faculty of Medicine , Medicinska fakulteten , Department of Experimental Medical Science , Membranproteinstrukturbiologi , LTH profilområde: Livsmedel och bioteknik , Lunds Tekniska Högskola , Lunds universitet , Faculty of Engineering, LTH , LTH Profile areas , LTH profilområden , Lund University , Institutionen för experimentell medicinsk vetenskap , LTH Profile Area: Food and Bio and Membrane Protein Structural Biology
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Copper transporting P-type (P
1B-1
-) ATPases are essential for cellular homeostasis. Nonetheless, the E1-E1P-E2P-E2 states mechanism of P
1B-1
-ATPases remains poorly understood. In particular, the role of the intrinsic metal binding domains (MBDs) is enigmatic. Here, four cryo-EM structures and molecular dynamics simulations of a P
Alternative Titles
Full title
Diverse roles of the metal binding domains and transport mechanism of copper transporting P-type ATPases
Authors, Artists and Contributors
Author / Creator
Orädd, Fredrik
Bågenholm, Viktoria
Grønberg, Christina
Ma, Jian Feng
Ott, Peter
Wang, Yong
Andersson, Magnus
Pedersen, Per Amstrup
Wang, Kaituo
Gourdon, Pontus
Faculty of Medicine
Medicinska fakulteten
Department of Experimental Medical Science
Membranproteinstrukturbiologi
LTH profilområde: Livsmedel och bioteknik
Lunds Tekniska Högskola
Lunds universitet
Faculty of Engineering, LTH
LTH Profile areas
LTH profilområden
Lund University
Institutionen för experimentell medicinsk vetenskap
LTH Profile Area: Food and Bio
Membrane Protein Structural Biology
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Primary Identifiers
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TN_cdi_doaj_primary_oai_doaj_org_article_0d4eadeac2dd4b0fac9c841dfb4fef71
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0d4eadeac2dd4b0fac9c841dfb4fef71
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-47001-4
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