Safety, pharmacokinetics, pharmacodynamics, and antitumor activity of SAR439459, a TGFβ inhibitor, a...
Safety, pharmacokinetics, pharmacodynamics, and antitumor activity of SAR439459, a TGFβ inhibitor, as monotherapy and in combination with cemiplimab in patients with advanced solid tumors: Findings from a phase 1/1b study
About this item
Full title
Author / Creator
Baranda, Joaquina C. , Robbrecht, Debbie , Sullivan, Ryan , Doger, Bernard , Santoro, Armando , Barve, Minal , Grob, Jean‐Jacques , Bechter, Oliver , Vieito, Maria , Miguel, Maria Jose , Schadendorf, Dirk , Johnson, Melissa , Pouzin, Clemence , Cantalloube, Cathy , Wang, Rui , Lee, Jooyun , Chen, Xiaofei , Demers, Brigitte , Amrate, Amele , Abbadessa, Giovanni and Hodi, F. Stephen
Publisher
United States: John Wiley & Sons, Inc
Journal title
Language
English
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Publication information
Publisher
United States: John Wiley & Sons, Inc
Subjects
More information
Scope and Contents
Contents
SAR439459 (SAR'459), a “second‐generation” human anti‐transforming growth factor beta (TGFβ) monoclonal antibody, enhances the activity of immune checkpoint inhibitors. In this phase I/Ib study, we evaluated the safety, pharmacokinetics (PK), pharmacodynamics, and antitumor activity of SAR'459 ± cemiplimab (intravenous) in patients with advanced so...
Alternative Titles
Full title
Safety, pharmacokinetics, pharmacodynamics, and antitumor activity of SAR439459, a TGFβ inhibitor, as monotherapy and in combination with cemiplimab in patients with advanced solid tumors: Findings from a phase 1/1b study
Authors, Artists and Contributors
Author / Creator
Robbrecht, Debbie
Sullivan, Ryan
Doger, Bernard
Santoro, Armando
Barve, Minal
Grob, Jean‐Jacques
Bechter, Oliver
Vieito, Maria
Miguel, Maria Jose
Schadendorf, Dirk
Johnson, Melissa
Pouzin, Clemence
Cantalloube, Cathy
Wang, Rui
Lee, Jooyun
Chen, Xiaofei
Demers, Brigitte
Amrate, Amele
Abbadessa, Giovanni
Hodi, F. Stephen
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_0d7ccfe237a8402d86c3353c80fd2923
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0d7ccfe237a8402d86c3353c80fd2923
Other Identifiers
ISSN
1752-8054,1752-8062
E-ISSN
1752-8062
DOI
10.1111/cts.13854
