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Transcriptional profiling reveals a subset of human breast tumors that retain wt TP53 but display mu...

Transcriptional profiling reveals a subset of human breast tumors that retain wt TP53 but display mu...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0e3731e53bbb46d18432564f83817490

Transcriptional profiling reveals a subset of human breast tumors that retain wt TP53 but display mutant p53‐associated features

About this item

Full title

Transcriptional profiling reveals a subset of human breast tumors that retain wt TP53 but display mutant p53‐associated features

Publisher

United States: John Wiley & Sons, Inc

Journal title

Molecular oncology, 2020-08, Vol.14 (8), p.1640-1652

Language

English

Formats

Publication information

Publisher

United States: John Wiley & Sons, Inc

More information

Scope and Contents

Contents

TP53 gene mutations are very common in human cancer. While such mutations abrogate the tumor suppressive activities of the wild‐type (wt) p53 protein, some of them also endow the mutant (mut) protein with oncogenic gain of function (GOF), facilitating cancer progression. Yet, p53 may acquire altered functionality even without being mutated; in part...

Alternative Titles

Full title

Transcriptional profiling reveals a subset of human breast tumors that retain wt TP53 but display mutant p53‐associated features

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_0e3731e53bbb46d18432564f83817490

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0e3731e53bbb46d18432564f83817490

Other Identifiers

ISSN

1574-7891,1878-0261

E-ISSN

1878-0261

DOI

10.1002/1878-0261.12736

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