Cell-type-specific Alzheimer’s disease polygenic risk scores are associated with distinct disease pr...
Cell-type-specific Alzheimer’s disease polygenic risk scores are associated with distinct disease processes in Alzheimer’s disease
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Author / Creator
Yang, Hyun-Sik , Teng, Ling , Kang, Daniel , Menon, Vilas , Ge, Tian , Finucane, Hilary K. , Schultz, Aaron P. , Properzi, Michael , Klein, Hans-Ulrich , Chibnik, Lori B. , Schneider, Julie A. , Bennett, David A. , Hohman, Timothy J. , Mayeux, Richard P. , Johnson, Keith A. , De Jager, Philip L. and Sperling, Reisa A.
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Many of the Alzheimer’s disease (AD) risk genes are specifically expressed in microglia and astrocytes, but how and when the genetic risk localizing to these cell types contributes to AD pathophysiology remains unclear. Here, we derive cell-type-specific AD polygenic risk scores (ADPRS) from two extensively characterized datasets and uncover the im...
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Cell-type-specific Alzheimer’s disease polygenic risk scores are associated with distinct disease processes in Alzheimer’s disease
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TN_cdi_doaj_primary_oai_doaj_org_article_0e512e3890b148e388c778ba58f1e579
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0e512e3890b148e388c778ba58f1e579
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-43132-2
