The distribution of a germline methylation marker suggests a regional mechanism of LINE-1 silencing...
The distribution of a germline methylation marker suggests a regional mechanism of LINE-1 silencing by the piRNA-PIWI system
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
A defense system against transposon activity in the human germline based on PIWI proteins and piRNA has recently been discovered. It represses the activity of LINE-1 elements via DNA methylation by a largely unknown mechanism. Based on the dispersed distribution of clusters of piRNA genes in a strand-specific manner on all human chromosomes, we hyp...
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Full title
The distribution of a germline methylation marker suggests a regional mechanism of LINE-1 silencing by the piRNA-PIWI system
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TN_cdi_doaj_primary_oai_doaj_org_article_0e873f35f6f144e596054b3261fa5962
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0e873f35f6f144e596054b3261fa5962
Other Identifiers
ISSN
1471-2156
E-ISSN
1471-2156
DOI
10.1186/1471-2156-13-31
