Structural basis for therapeutic inhibition of influenza A polymerase PB2 subunit
Structural basis for therapeutic inhibition of influenza A polymerase PB2 subunit
About this item
Full title
Author / Creator
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States). Advanced Light Source (ALS) , Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS) , Ma, Xiaolei , Xie, Lili , Wartchow, Charles , Warne, Robert , Xu, Yongjin , Rivkin, Alexey , Tully, David , Shia, Steven , Uehara, Kyoko , Baldwin, Dianna M. , Muiru, Gladys , Zhong, Weidong , Zaror, Isabel , Bussiere, Dirksen E. and Leonard, Vincent H. J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Influenza virus uses a unique mechanism to initiate viral transcription named cap-snatching. The PB2 subunit of the viral heterotrimeric RNA polymerase binds the cap structure of cellular pre-mRNA to promote its cleavage by the PA subunit. The resulting 11–13 capped oligomer is used by the PB1 polymerase subunit to initiate transcription of viral p...
Alternative Titles
Full title
Structural basis for therapeutic inhibition of influenza A polymerase PB2 subunit
Authors, Artists and Contributors
Author / Creator
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Ma, Xiaolei
Xie, Lili
Wartchow, Charles
Warne, Robert
Xu, Yongjin
Rivkin, Alexey
Tully, David
Shia, Steven
Uehara, Kyoko
Baldwin, Dianna M.
Muiru, Gladys
Zhong, Weidong
Zaror, Isabel
Bussiere, Dirksen E.
Leonard, Vincent H. J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_0e992cb2a2914995a1aae7e6664172d2
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0e992cb2a2914995a1aae7e6664172d2
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-017-09538-x
