Cyclic GMP-AMP Ameliorates Diet-induced Metabolic Dysregulation and Regulates Proinflammatory Respon...
Cyclic GMP-AMP Ameliorates Diet-induced Metabolic Dysregulation and Regulates Proinflammatory Responses Distinctly from STING Activation
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Author / Creator
Guo, Xin , Shu, Chang , Li, Honggui , Pei, Ya , Woo, Shih-Lung , Zheng, Juan , Liu, Mengyang , Xu, Hang , Botchlett, Rachel , Guo, Ting , Cai, Yuli , Gao, Xinsheng , Zhou, Jing , Chen, Lu , Li, Qifu , Xiao, Xiaoqiu , Xie, Linglin , Zhang, Ke K. , Ji, Jun-Yuan , Huo, Yuqing , Meng, Fanyin , Alpini, Gianfranco , Li, Pingwei and Wu, Chaodong
Publisher
London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
Endogenous cyclic GMP-AMP (cGAMP) binds and activates STING to induce type I interferons. However, whether cGAMP plays any roles in regulating metabolic homeostasis remains unknown. Here we show that exogenous cGAMP ameliorates obesity-associated metabolic dysregulation and uniquely alters proinflammatory responses. In obese mice, treatment with cG...
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Full title
Cyclic GMP-AMP Ameliorates Diet-induced Metabolic Dysregulation and Regulates Proinflammatory Responses Distinctly from STING Activation
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TN_cdi_doaj_primary_oai_doaj_org_article_0eb94b4ac1234b1abef97562d680489e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0eb94b4ac1234b1abef97562d680489e
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-017-05884-y
