Supraphysiologic doses of 17β-estradiol aggravate depression-like behaviors in ovariectomized mice p...
Supraphysiologic doses of 17β-estradiol aggravate depression-like behaviors in ovariectomized mice possibly via regulating microglial responses and brain glycerophospholipid metabolism
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Author / Creator
Li, Ming , Zhang, Jing , Chen, Wendi , Liu, Shuang , Liu, Xin , Ning, Yunna , Cao, Yongzhi and Zhao, Yueran
Publisher
London: BioMed Central
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Language
English
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Publisher
London: BioMed Central
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Background17β-Estradiol (E2) is generally considered neuroprotective in humans. However, the current clinical use of estrogen replacement therapy (ERT) is based on the physiological dose of E2 to treat menopausal syndrome and has limited therapeutic efficacy. The efficacy and potential toxicity of superphysiological doses of ERT for menopausal neur...
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Full title
Supraphysiologic doses of 17β-estradiol aggravate depression-like behaviors in ovariectomized mice possibly via regulating microglial responses and brain glycerophospholipid metabolism
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TN_cdi_doaj_primary_oai_doaj_org_article_0ec35626dd3948f3bf7569a0667b4cc2
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0ec35626dd3948f3bf7569a0667b4cc2
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ISSN
1742-2094
E-ISSN
1742-2094
DOI
10.1186/s12974-023-02889-5
