Experimental factors that impact CaV1.2 channel pharmacology—Effects of recording temperature, charg...
Experimental factors that impact CaV1.2 channel pharmacology—Effects of recording temperature, charge carrier, and quantification of drug effects on the step and ramp currents elicited by the “step-step-ramp” voltage protocol
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United States: Public Library of Science
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English
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United States: Public Library of Science
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CaV1.2 channels contribute to action potential upstroke in pacemaker cells, plateau potential in working myocytes, and initiate excitation-contraction coupling. Understanding drug action on CaV1.2 channels may inform potential impact on cardiac function. However, literature shows large degrees of variability between CaV1.2 pharmacology generated by...
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Full title
Experimental factors that impact CaV1.2 channel pharmacology—Effects of recording temperature, charge carrier, and quantification of drug effects on the step and ramp currents elicited by the “step-step-ramp” voltage protocol
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TN_cdi_doaj_primary_oai_doaj_org_article_0ed99cc9c9064ac28b84b9d7a7da82fd
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0ed99cc9c9064ac28b84b9d7a7da82fd
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0276995
