Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants
Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants
About this item
Full title
Author / Creator
Hayes, Tikvah K. , Aquilanti, Elisa , Persky, Nicole S. , Yang, Xiaoping , Kim, Erica E. , Brenan, Lisa , Goodale, Amy B. , Alan, Douglas , Sharpe, Ted , Shue, Robert E. , Westlake, Lindsay , Golomb, Lior , Silverman, Brianna R. , Morris, Myshal D. , Fisher, Ty Running , Beyene, Eden , Li, Yvonne Y. , Cherniack, Andrew D. , Piccioni, Federica , Hicks, J. Kevin , Chi, Andrew S. , Cahill, Daniel P. , Dietrich, Jorg , Batchelor, Tracy T. , Root, David E. , Johannessen, Cory M. and Meyerson, Matthew
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The epidermal growth factor receptor, EGFR, is frequently activated in lung cancer and glioblastoma by genomic alterations including missense mutations. The different mutation spectra in these diseases are reflected in divergent responses to EGFR inhibition: significant patient benefit in lung cancer, but limited in glioblastoma. Here, we report a...
Alternative Titles
Full title
Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants
Authors, Artists and Contributors
Author / Creator
Aquilanti, Elisa
Persky, Nicole S.
Yang, Xiaoping
Kim, Erica E.
Brenan, Lisa
Goodale, Amy B.
Alan, Douglas
Sharpe, Ted
Shue, Robert E.
Westlake, Lindsay
Golomb, Lior
Silverman, Brianna R.
Morris, Myshal D.
Fisher, Ty Running
Beyene, Eden
Li, Yvonne Y.
Cherniack, Andrew D.
Piccioni, Federica
Hicks, J. Kevin
Chi, Andrew S.
Cahill, Daniel P.
Dietrich, Jorg
Batchelor, Tracy T.
Root, David E.
Johannessen, Cory M.
Meyerson, Matthew
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_0edde2f4b771457398e829246efe16d1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0edde2f4b771457398e829246efe16d1
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-45594-4
