Conformational dynamics of the human serotonin transporter during substrate and drug binding
Conformational dynamics of the human serotonin transporter during substrate and drug binding
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
The serotonin transporter (SERT), a member of the neurotransmitter:sodium symporter family, is responsible for termination of serotonergic signaling by re-uptake of serotonin (5-HT) into the presynaptic neuron. Its key role in synaptic transmission makes it a major drug target, e.g. for the treatment of depression, anxiety and post-traumatic stress...
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Full title
Conformational dynamics of the human serotonin transporter during substrate and drug binding
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TN_cdi_doaj_primary_oai_doaj_org_article_0eff74681cb349509bf0274d56961747
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0eff74681cb349509bf0274d56961747
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-09675-z
