Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s dise...
Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis
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Author / Creator
Carballo-Carbajal, Iria , Laguna, Ariadna , Romero-Giménez, Jordi , Cuadros, Thais , Bové, Jordi , Martinez-Vicente, Marta , Parent, Annabelle , Gonzalez-Sepulveda, Marta , Peñuelas, Núria , Torra, Albert , Rodríguez-Galván, Beatriz , Ballabio, Andrea , Hasegawa, Takafumi , Bortolozzi, Analía , Gelpi, Ellen and Vila, Miquel
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
In Parkinson’s disease (PD) there is a selective degeneration of neuromelanin-containing neurons, especially substantia nigra dopaminergic neurons. In humans, neuromelanin accumulates with age, the latter being the main risk factor for PD. The contribution of neuromelanin to PD pathogenesis remains unknown because, unlike humans, common laboratory...
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Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis
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TN_cdi_doaj_primary_oai_doaj_org_article_0fbc1ef6e5e046b1873667d6a11b3aa6
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0fbc1ef6e5e046b1873667d6a11b3aa6
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-08858-y
