Intramolecular interaction kinetically regulates fibril formation by human and mouse α-synuclein
Intramolecular interaction kinetically regulates fibril formation by human and mouse α-synuclein
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Regulation of α-synuclein (αS) fibril formation is a potent therapeutic strategy for αS-related neurodegenerative disorders. αS, an intrinsically disordered 140-residue intraneural protein, comprises positively charged N-terminal, hydrophobic non-amyloid β component (NAC), and negatively charged C-terminal regions. Although mouse and human αS share...
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Intramolecular interaction kinetically regulates fibril formation by human and mouse α-synuclein
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TN_cdi_doaj_primary_oai_doaj_org_article_10610d7d92d34ae0ab1fa5b064e5d988
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_10610d7d92d34ae0ab1fa5b064e5d988
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-023-38070-4
