Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signal...
Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin
About this item
Full title
Author / Creator
Kim, Hyosung , Leng, Kun , Park, Jinhee , Sorets, Alexander G. , Kim, Suil , Shostak, Alena , Embalabala, Rebecca J. , Mlouk, Kate , Katdare, Ketaki A. , Rose, Indigo V. L. , Sturgeon, Sarah M. , Neal, Emma H. , Ao, Yan , Wang, Shinong , Sofroniew, Michael V. , Brunger, Jonathan M. , McMahon, Douglas G. , Schrag, Matthew S. , Kampmann, Martin and Lippmann, Ethan S.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Astrocytes are critical components of the neurovascular unit that support blood-brain barrier (BBB) function. Pathological transformation of astrocytes to reactive states can be protective or harmful to BBB function. Here, using a human induced pluripotent stem cell (iPSC)-derived BBB co-culture model, we show that tumor necrosis factor (TNF) trans...
Alternative Titles
Full title
Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin
Authors, Artists and Contributors
Author / Creator
Leng, Kun
Park, Jinhee
Sorets, Alexander G.
Kim, Suil
Shostak, Alena
Embalabala, Rebecca J.
Mlouk, Kate
Katdare, Ketaki A.
Rose, Indigo V. L.
Sturgeon, Sarah M.
Neal, Emma H.
Ao, Yan
Wang, Shinong
Sofroniew, Michael V.
Brunger, Jonathan M.
McMahon, Douglas G.
Schrag, Matthew S.
Kampmann, Martin
Lippmann, Ethan S.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_106dfd6155e1471aa3dfbd079fe49bd4
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_106dfd6155e1471aa3dfbd079fe49bd4
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-34412-4
