In Vivo and In Vitro Activities and ADME-Tox Profile of a Quinolizidine-Modified 4-Aminoquinoline: A...
In Vivo and In Vitro Activities and ADME-Tox Profile of a Quinolizidine-Modified 4-Aminoquinoline: A Potent Anti-P. falciparum and Anti-P. vivax Blood-Stage Antimalarial
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Basilico, Nicoletta , Parapini, Silvia , Sparatore, Anna , Romeo, Sergio , Misiano, Paola , Vivas, Livia , Yardley, Vanessa , Croft, Simon , Habluetzel, Annette , Lucantoni, Leonardo , Renia, Laurent , Russell, Bruce , Suwanarusk, Rossarin , Nosten, Francois , Dondio, Giulio , Bigogno, Chiara , Jabes, Daniela and Taramelli, Donatella
Publisher
Switzerland: MDPI AG
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Language
English
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Publisher
Switzerland: MDPI AG
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Contents
Natural products are a prolific source for the identification of new biologically active compounds. In the present work, we studied the in vitro and in vivo antimalarial efficacy and ADME-Tox profile of a molecular hybrid (AM1) between 4-aminoquinoline and a quinolizidine moiety derived from lupinine (Lupinus luteus). The aim was to find a compound...
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Full title
In Vivo and In Vitro Activities and ADME-Tox Profile of a Quinolizidine-Modified 4-Aminoquinoline: A Potent Anti-P. falciparum and Anti-P. vivax Blood-Stage Antimalarial
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TN_cdi_doaj_primary_oai_doaj_org_article_109aa3a57b6d49ebb3938d568b370008
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_109aa3a57b6d49ebb3938d568b370008
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ISSN
1420-3049
E-ISSN
1420-3049
DOI
10.3390/molecules22122102
