Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis
Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Merely touching the pancreas can lead to premature zymogen activation and pancreatitis but the mechanism is not completely understood. Here we demonstrate that pancreatic acinar cells express the mechanoreceptor Piezo1 and application of pressure within the gland produces pancreatitis. To determine if this effect is through Piezo1 activation, we in...
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Full title
Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis
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TN_cdi_doaj_primary_oai_doaj_org_article_10e1a87d36af415ca7fb7de77dc16ef2
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_10e1a87d36af415ca7fb7de77dc16ef2
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-04194-9
