A mouse model of human mitofusin-2-related lipodystrophy exhibits adipose-specific mitochondrial str...
A mouse model of human mitofusin-2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion
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Author / Creator
Mann, Jake P , Duan, Xiaowen , Patel, Satish , Tábara, Luis Carlos , Scurria, Fabio , Alvarez-Guaita, Anna , Haider, Afreen , Luijten, Ineke , Page, Matthew , Protasoni, Margherita , Lim, Koini , Virtue, Sam , O'Rahilly, Stephen , Armstrong, Martin , Prudent, Julien , Semple, Robert K and Savage, David B
Publisher
England: eLife Sciences Publications, Ltd
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Language
English
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Publisher
England: eLife Sciences Publications, Ltd
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Contents
Mitochondrial dysfunction has been reported in obesity and insulin resistance, but primary genetic mitochondrial dysfunction is generally not associated with these, arguing against a straightforward causal relationship. A rare exception, recently identified in humans, is a syndrome of lower body adipose loss, leptin-deficient severe upper body adip...
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Full title
A mouse model of human mitofusin-2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion
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TN_cdi_doaj_primary_oai_doaj_org_article_10fcb30f48a744fd966e20290cf355fb
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_10fcb30f48a744fd966e20290cf355fb
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.82283
