Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host...
Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses
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Author / Creator
van der Plas, Mariena J. A. , Bhongir, Ravi K. V. , Kjellström, Sven , Siller, Helena , Kasetty, Gopinath , Mörgelin, Matthias , Schmidtchen, Artur , Faculty of Medicine , Medicinska fakulteten , Naturvetenskapliga fakulteten , Sektion III , Department of Chemistry , Biokemi och Strukturbiologi , Institutionen för kliniska vetenskaper, Lund , Center for Molecular Protein Science , Kemiska institutionen , Dermatology and Venereology (Lund) , Lunds universitet , Faculty of Science , Centrum för Molekylär Proteinvetenskap , Department of Clinical Sciences, Lund , Biochemistry and Structural Biology , Lund University , Section III , Dermatologi och venereologi, Lund , Infection Medicine (BMC) and Infektionsmedicin
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Pseudomonas aeruginosa
is an opportunistic pathogen known for its immune evasive abilities amongst others by degradation of a large variety of host proteins. Here we show that digestion of thrombin by
P. aeruginosa
elastase leads to the release of the C-terminal thrombin-derived peptide FYT21, which inhibits pro-inflammatory responses to s...
Alternative Titles
Full title
Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses
Authors, Artists and Contributors
Author / Creator
Bhongir, Ravi K. V.
Kjellström, Sven
Siller, Helena
Kasetty, Gopinath
Mörgelin, Matthias
Schmidtchen, Artur
Faculty of Medicine
Medicinska fakulteten
Naturvetenskapliga fakulteten
Sektion III
Department of Chemistry
Biokemi och Strukturbiologi
Institutionen för kliniska vetenskaper, Lund
Center for Molecular Protein Science
Kemiska institutionen
Dermatology and Venereology (Lund)
Lunds universitet
Faculty of Science
Centrum för Molekylär Proteinvetenskap
Department of Clinical Sciences, Lund
Biochemistry and Structural Biology
Lund University
Section III
Dermatologi och venereologi, Lund
Infection Medicine (BMC)
Infektionsmedicin
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_1143f94b90fb4bf195cbd8188246946e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1143f94b90fb4bf195cbd8188246946e
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms11567
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