Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specializat...
Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Differentiation is critical for cell fate decisions, but the signals involved remain unclear. The kidney proximal tubule (PT) cells reabsorb disulphide-rich proteins through endocytosis, generating cystine via lysosomal proteolysis. Here we report that defective cystine mobilization from lysosomes through cystinosin (CTNS), which is mutated in cyst...
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Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization
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TN_cdi_doaj_primary_oai_doaj_org_article_11a5f48d3b2345418cf8893bc3e0feb9
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_11a5f48d3b2345418cf8893bc3e0feb9
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-39261-3
