Influenza A virus NS1 gene mutations F103L and M106I increase replication and virulence
Influenza A virus NS1 gene mutations F103L and M106I increase replication and virulence
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
To understand the evolutionary steps required for a virus to become virulent in a new host, a human influenza A virus (IAV), A/Hong Kong/1/68(H3N2) (HK-wt), was adapted to increased virulence in the mouse. Among eleven mutations selected in the NS1 gene, two mutations F103L and M106I had been previously detected in the highly virulent human H5N1 is...
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Full title
Influenza A virus NS1 gene mutations F103L and M106I increase replication and virulence
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TN_cdi_doaj_primary_oai_doaj_org_article_11b095596ee8453887e86a5d33f24f72
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_11b095596ee8453887e86a5d33f24f72
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ISSN
1743-422X
E-ISSN
1743-422X
DOI
10.1186/1743-422X-8-13
