Mutations of Glu560 within HIV-1 Envelope Glycoprotein N-terminal heptad repeat region contribute to...
Mutations of Glu560 within HIV-1 Envelope Glycoprotein N-terminal heptad repeat region contribute to resistance to peptide inhibitors of virus entry
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Author / Creator
Yuan, Chen , Wang, Jia-Ye , Zhao, Hai-Jiao , Li, Yan , Li, Di , Ling, Hong and Zhuang, Min
Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publication information
Publisher
England: BioMed Central Ltd
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Scope and Contents
Contents
Peptides corresponding to N- and C-terminal heptad repeat regions (HR1 and HR2, respectively) of gp41 can inhibit HIV-1 infection in a dominant negative manner by interfering with refolding of the viral HR1 and HR2 to form a six-helix bundle (6HB) that induces fusion between viral and host cell membranes. Previously, we found that HIV-1 acquired th...
Alternative Titles
Full title
Mutations of Glu560 within HIV-1 Envelope Glycoprotein N-terminal heptad repeat region contribute to resistance to peptide inhibitors of virus entry
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_121da5dc1c4849059d5f8c79eecb76d2
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_121da5dc1c4849059d5f8c79eecb76d2
Other Identifiers
ISSN
1742-4690
E-ISSN
1742-4690
DOI
10.1186/s12977-019-0496-8
