MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer
MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer
About this item
Full title
Author / Creator
Yasumizu, Yota , Rajabi, Hasan , Jin, Caining , Hata, Tsuyoshi , Pitroda, Sean , Long, Mark D. , Hagiwara, Masayuki , Li, Wei , Hu, Qiang , Liu, Song , Yamashita, Nami , Fushimi, Atsushi , Kui, Ling , Samur, Mehmet , Yamamoto, Masaaki , Zhang, Yan , Zhang, Ning , Hong, Deli , Maeda, Takahiro , Kosaka, Takeo , Wong, Kwok K. , Oya, Mototsugu and Kufe, Donald
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Neuroendocrine prostate cancer (NEPC) is an aggressive malignancy with no effective targeted therapies. The oncogenic MUC1-C protein is overexpressed in castration-resistant prostate cancer (CRPC) and NEPC, but its specific role is unknown. Here, we demonstrate that upregulation of MUC1-C in androgen-dependent PC cells suppresses androgen receptor...
Alternative Titles
Full title
MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer
Authors, Artists and Contributors
Author / Creator
Rajabi, Hasan
Jin, Caining
Hata, Tsuyoshi
Pitroda, Sean
Long, Mark D.
Hagiwara, Masayuki
Li, Wei
Hu, Qiang
Liu, Song
Yamashita, Nami
Fushimi, Atsushi
Kui, Ling
Samur, Mehmet
Yamamoto, Masaaki
Zhang, Yan
Zhang, Ning
Hong, Deli
Maeda, Takahiro
Kosaka, Takeo
Wong, Kwok K.
Oya, Mototsugu
Kufe, Donald
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_122d971bc14145f181528834a1ae353b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_122d971bc14145f181528834a1ae353b
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-14219-6
