YAP is essential for mechanical force production and epithelial cell proliferation during lung branc...
YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis
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Publisher
England: eLife Science Publications, Ltd
Journal title
Language
English
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Publisher
England: eLife Science Publications, Ltd
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Contents
Branching morphogenesis is a fundamental program for tissue patterning. We show that active YAP, a key mediator of Hippo signaling, is distributed throughout the murine lung epithelium and loss of epithelial YAP severely disrupts branching. Failure to branch is restricted to regions where YAP activity is removed. This suggests that YAP controls loc...
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Full title
YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis
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TN_cdi_doaj_primary_oai_doaj_org_article_123c30f24c1445399862763c9f4a61ec
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_123c30f24c1445399862763c9f4a61ec
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.21130
