Spatial transcriptomics reveals tumor-derived SPP1 induces fibroblast chemotaxis and activation in t...
Spatial transcriptomics reveals tumor-derived SPP1 induces fibroblast chemotaxis and activation in the hepatocellular carcinoma microenvironment
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Publisher
England: BioMed Central Ltd
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Language
English
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England: BioMed Central Ltd
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The tumor microenvironment (TME) exerts profound effects on tumor progression and therapeutic efficacy. In hepatocellular carcinoma (HCC), the TME is enriched with cancer-associated fibroblasts (CAFs), which secrete a plethora of cytokines, chemokines, and growth factors that facilitate tumor cell proliferation and invasion. However, the intricate...
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Spatial transcriptomics reveals tumor-derived SPP1 induces fibroblast chemotaxis and activation in the hepatocellular carcinoma microenvironment
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TN_cdi_doaj_primary_oai_doaj_org_article_12475b3f580e4025bd215d09e113760f
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_12475b3f580e4025bd215d09e113760f
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ISSN
1479-5876
E-ISSN
1479-5876
DOI
10.1186/s12967-024-05613-w
