FUT8-mediated aberrant N-glycosylation of B7H3 suppresses the immune response in triple-negative bre...
FUT8-mediated aberrant N-glycosylation of B7H3 suppresses the immune response in triple-negative breast cancer
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Author / Creator
Huang, Yun , Zhang, Hai-Liang , Li, Zhi-Ling , Du, Tian , Chen, Yu-Hong , Wang, Yan , Ni, Huan-He , Zhang, Kai-Ming , Mai, Jia , Hu, Bing-Xin , Huang, Jun-Hao , Zhou, Li-Huan , Yang, Dong , Peng, Xiao-Dan , Feng, Gong-Kan , Tang, Jun , Zhu, Xiao-Feng and Deng, Rong
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Most patients with triple negative breast cancer (TNBC) do not respond to anti-PD1/PDL1 immunotherapy, indicating the necessity to explore immune checkpoint targets. B7H3 is a highly glycosylated protein. However, the mechanisms of B7H3 glycosylation regulation and whether the sugar moiety contributes to immunosuppression are unclear. Here, we iden...
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Full title
FUT8-mediated aberrant N-glycosylation of B7H3 suppresses the immune response in triple-negative breast cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_1258b476d9c94dcb951013c2b2aa4bd4
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1258b476d9c94dcb951013c2b2aa4bd4
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-22618-x
