Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid me...
Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism
About this item
Full title
Author / Creator
Arbore, Giuseppina , West, Erin E. , Rahman, Jubayer , Le Friec, Gaelle , Niyonzima, Nathalie , Pirooznia, Mehdi , Tunc, Ilker , Pavlidis, Polychronis , Powell, Nicholas , Li, Yuesheng , Liu, Poching , Servais, Aude , Couzi, Lionel , Fremeaux-Bacchi, Veronique , Placais, Leo , Ferraro, Alastair , Walsh, Patrick R. , Kavanagh, David , Afzali, Behdad , Lavender, Paul , Lachmann, Helen J. and Kemper, Claudia
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The induction of human CD4
+
Th1 cells requires autocrine stimulation of the complement receptor CD46 in direct crosstalk with a CD4
+
T cell-intrinsic NLRP3 inflammasome. However, it is unclear whether human cytotoxic CD8
+
T cell (CTL) responses also rely on an intrinsic complement-inflammasome axis. Here we show, using CTLs fro...
Alternative Titles
Full title
Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism
Authors, Artists and Contributors
Author / Creator
West, Erin E.
Rahman, Jubayer
Le Friec, Gaelle
Niyonzima, Nathalie
Pirooznia, Mehdi
Tunc, Ilker
Pavlidis, Polychronis
Powell, Nicholas
Li, Yuesheng
Liu, Poching
Servais, Aude
Couzi, Lionel
Fremeaux-Bacchi, Veronique
Placais, Leo
Ferraro, Alastair
Walsh, Patrick R.
Kavanagh, David
Afzali, Behdad
Lavender, Paul
Lachmann, Helen J.
Kemper, Claudia
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_12d27a6322604934916857f1fe60bd7c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_12d27a6322604934916857f1fe60bd7c
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-06706-z
