The multiple myeloma risk allele at 5q15 lowers ELL2 expression and increases ribosomal gene express...
The multiple myeloma risk allele at 5q15 lowers ELL2 expression and increases ribosomal gene expression
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Author / Creator
Faculty of Medicine , Medicinska fakulteten , Strategiska forskningsområden (SFO) , Undersökning av molekylära sjukdomsmekanismer vid blodcancer , Department of Laboratory Medicine , Division of Hematology and Clinical Immunology , Avdelningen för hematologi och klinisk immunologi , EpiHealth: Epidemiology for Health , Institutionen för kliniska vetenskaper, Malmö , Hematogenomics , Myeloma research group , Strategic research areas (SRA) , Lunds universitet , Myelomgruppen , Family Medicine and Clinical Epidemiology , Profilområden och andra starka forskningsmiljöer , Lund University , Institutionen för laboratoriemedicin , Allmänmedicin och klinisk epidemiologi , Transcriptional mechanisms for the Wilms’ tumor gene 1 (WT1) oncoprotein , Profile areas and other strong research environments , Department of Clinical Sciences, Malmö , Ali, Mina , Ajore, Ram , Wihlborg, Anna-Karin , Niroula, Abhishek , Swaminathan, Bhairavi , Johnsson, Ellinor , Stephens, Owen W , Morgan, Gareth , Meissner, Tobias , Turesson, Ingemar , Goldschmidt, Hartmut , Mellqvist, Ulf-Henrik , Gullberg, Urban , Hansson, Markus , Hemminki, Kari , Nahi, Hareth , Waage, Anders , Weinhold, Niels and Nilsson, Björn
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Recently, we identified
ELL2
as a susceptibility gene for multiple myeloma (MM). To understand its mechanism of action, we performed expression quantitative trait locus analysis in CD138
+
plasma cells from 1630 MM patients from four populations. We show that the MM risk allele lowers
ELL2
expression in these cells (
P
combi...
Alternative Titles
Full title
The multiple myeloma risk allele at 5q15 lowers ELL2 expression and increases ribosomal gene expression
Authors, Artists and Contributors
Author / Creator
Medicinska fakulteten
Strategiska forskningsområden (SFO)
Undersökning av molekylära sjukdomsmekanismer vid blodcancer
Department of Laboratory Medicine
Division of Hematology and Clinical Immunology
Avdelningen för hematologi och klinisk immunologi
EpiHealth: Epidemiology for Health
Institutionen för kliniska vetenskaper, Malmö
Hematogenomics
Myeloma research group
Strategic research areas (SRA)
Lunds universitet
Myelomgruppen
Family Medicine and Clinical Epidemiology
Profilområden och andra starka forskningsmiljöer
Lund University
Institutionen för laboratoriemedicin
Allmänmedicin och klinisk epidemiologi
Transcriptional mechanisms for the Wilms’ tumor gene 1 (WT1) oncoprotein
Profile areas and other strong research environments
Department of Clinical Sciences, Malmö
Ali, Mina
Ajore, Ram
Wihlborg, Anna-Karin
Niroula, Abhishek
Swaminathan, Bhairavi
Johnsson, Ellinor
Stephens, Owen W
Morgan, Gareth
Meissner, Tobias
Turesson, Ingemar
Goldschmidt, Hartmut
Mellqvist, Ulf-Henrik
Gullberg, Urban
Hansson, Markus
Hemminki, Kari
Nahi, Hareth
Waage, Anders
Weinhold, Niels
Nilsson, Björn
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_13489db4fa564fee8966c2324c237725
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_13489db4fa564fee8966c2324c237725
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-04082-2
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