p21 promotes oncolytic adenoviral activity in ovarian cancer and is a potential biomarker
p21 promotes oncolytic adenoviral activity in ovarian cancer and is a potential biomarker
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
The oncolytic adenovirus
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922-947 replicates selectively within and lyses cells with a dysregulated Rb pathway, a finding seen in > 90% human cancers.
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922-947 is more potent than wild type adenovirus and the E1B-deletion mutant
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1520 (Onyx-015). We wished to determine which host cell factors influence cytotoxicity. SV40 lar...
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Full title
p21 promotes oncolytic adenoviral activity in ovarian cancer and is a potential biomarker
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TN_cdi_doaj_primary_oai_doaj_org_article_13dfc844c9d54bfa95357eac97e4027f
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_13dfc844c9d54bfa95357eac97e4027f
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ISSN
1476-4598
E-ISSN
1476-4598
DOI
10.1186/1476-4598-9-175
