TadA orthologs enable both cytosine and adenine editing of base editors
TadA orthologs enable both cytosine and adenine editing of base editors
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Cytidine and adenosine deaminases are required for cytosine and adenine editing of base editors respectively, and no single deaminase could enable concurrent and comparable cytosine and adenine editing. Additionally, distinct properties of cytidine and adenosine deaminases lead to various types of off-target effects, including Cas9-indendepent DNA...
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Full title
TadA orthologs enable both cytosine and adenine editing of base editors
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TN_cdi_doaj_primary_oai_doaj_org_article_13fc781cbc734781ab4580fbbd6effeb
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_13fc781cbc734781ab4580fbbd6effeb
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-36003-3
