Peptide Nucleic Acids and Gene Editing: Perspectives on Structure and Repair
Peptide Nucleic Acids and Gene Editing: Perspectives on Structure and Repair
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Publisher
Switzerland: MDPI AG
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Language
English
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Publisher
Switzerland: MDPI AG
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Contents
Unusual nucleic acid structures are salient triggers of endogenous repair and can occur in sequence-specific contexts. Peptide nucleic acids (PNAs) rely on these principles to achieve non-enzymatic gene editing. By forming high-affinity heterotriplex structures within the genome, PNAs have been used to correct multiple human disease-relevant mutati...
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Full title
Peptide Nucleic Acids and Gene Editing: Perspectives on Structure and Repair
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TN_cdi_doaj_primary_oai_doaj_org_article_1457246a1487470b8e747bc56cd3198e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1457246a1487470b8e747bc56cd3198e
Other Identifiers
ISSN
1420-3049
E-ISSN
1420-3049
DOI
10.3390/molecules25030735
