Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes
Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes
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England: eLife Science Publications, Ltd
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English
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England: eLife Science Publications, Ltd
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Leucine-rich repeat kinase 2 (LRRK2) variants associated with Parkinson's disease (PD) and Crohn's disease lead to increased phosphorylation of its Rab substrates. While it has been recently shown that perturbations in cellular homeostasis including lysosomal damage can increase LRRK2 activity and localization to lysosomes, the molecular mechanisms...
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Full title
Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes
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TN_cdi_doaj_primary_oai_doaj_org_article_1459c4b9a28a4c35be189566695ad7a3
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1459c4b9a28a4c35be189566695ad7a3
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.87255
