Hydration effects on the efficacy of the Epidermal growth factor receptor kinase inhibitor afatinib
Hydration effects on the efficacy of the Epidermal growth factor receptor kinase inhibitor afatinib
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Small molecules targeting the
EGFR
tyrosine kinase domain have been used with some success at treating patients with non-small cell lung cancer driven by activating mutations in the kinase domain. The initial class of inhibitors displaced ATP noncovalently but were rendered ineffective due to the development of resistance mutations in the kin...
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Full title
Hydration effects on the efficacy of the Epidermal growth factor receptor kinase inhibitor afatinib
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TN_cdi_doaj_primary_oai_doaj_org_article_145a6170f8624c79b228e5d534e4ff3b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_145a6170f8624c79b228e5d534e4ff3b
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-017-01491-z
