Macrophage depletion blocks congenital SARM1-dependent neuropathy
Macrophage depletion blocks congenital SARM1-dependent neuropathy
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Publisher
United States: American Society for Clinical Investigation
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Language
English
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Publisher
United States: American Society for Clinical Investigation
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Contents
Axon loss contributes to many common neurodegenerative disorders. In healthy axons, the axon survival factor NMNAT2 inhibits SARM1, the central executioner of programmed axon degeneration. We identified 2 rare NMNAT2 missense variants in 2 brothers afflicted with a progressive neuropathy syndrome. The polymorphisms resulted in amino acid substituti...
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Full title
Macrophage depletion blocks congenital SARM1-dependent neuropathy
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TN_cdi_doaj_primary_oai_doaj_org_article_1463d2560add407bbb4937358ec40312
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1463d2560add407bbb4937358ec40312
Other Identifiers
ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI159800
