Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and...
Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3
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Author / Creator
Faculty of Medicine , Medicinska fakulteten , Naturvetenskapliga fakulteten , Department of Chemistry , Department of Laboratory Medicine , Kemiska institutionen , Division of Microbiology, Immunology and Glycobiology - MIG , Lunds universitet , Faculty of Science , Centrum för analys och syntes , Lund University , Institutionen för laboratoriemedicin , Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG , Centre for Analysis and Synthesis , Chen, Wei-Sheng , Cao, Zhiyi , Sugaya, Satoshi , Lopez, Maria J. , Sendra, Victor G. , Laver, Nora , Leffler, Hakon , Nilsson, Ulf J. , Fu, Jianxin , Song, Jianhua , Xia, Lijun , Hamrah, Pedram and Panjwani, Noorjahan
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Lymphangiogenesis plays a pivotal role in diverse pathological conditions. Here, we demonstrate that a carbohydrate-binding protein, galectin-8, promotes pathological lymphangiogenesis. Galectin-8 is markedly upregulated in inflamed human and mouse corneas, and galectin-8 inhibitors reduce inflammatory lymphangiogenesis. In the mouse model of corne...
Alternative Titles
Full title
Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3
Authors, Artists and Contributors
Author / Creator
Medicinska fakulteten
Naturvetenskapliga fakulteten
Department of Chemistry
Department of Laboratory Medicine
Kemiska institutionen
Division of Microbiology, Immunology and Glycobiology - MIG
Lunds universitet
Faculty of Science
Centrum för analys och syntes
Lund University
Institutionen för laboratoriemedicin
Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG
Centre for Analysis and Synthesis
Chen, Wei-Sheng
Cao, Zhiyi
Sugaya, Satoshi
Lopez, Maria J.
Sendra, Victor G.
Laver, Nora
Leffler, Hakon
Nilsson, Ulf J.
Fu, Jianxin
Song, Jianhua
Xia, Lijun
Hamrah, Pedram
Panjwani, Noorjahan
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_14686d808c8b43c99af933249da04056
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_14686d808c8b43c99af933249da04056
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms11302
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