The tumour metabolism inhibitors GSAO and PENAO react with cysteines 57 and 257 of mitochondrial ade...
The tumour metabolism inhibitors GSAO and PENAO react with cysteines 57 and 257 of mitochondrial adenine nucleotide translocase
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England: BioMed Central Ltd
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English
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England: BioMed Central Ltd
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GSAO (4-(N-(S-glutathionylacetyl)amino) phenylarsonous acid) and PENAO (4-(N-(S-penicillaminylacetyl)amino) phenylarsonous acid) are tumour metabolism inhibitors that target adenine nucleotide translocase (ANT) of the inner-mitochondrial membrane. Both compounds are currently being trialled in patients with solid tumours. The trivalent arsenical mo...
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The tumour metabolism inhibitors GSAO and PENAO react with cysteines 57 and 257 of mitochondrial adenine nucleotide translocase
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TN_cdi_doaj_primary_oai_doaj_org_article_14b8dbfbfd55438ebb32c9d2e4f087ad
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_14b8dbfbfd55438ebb32c9d2e4f087ad
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ISSN
1475-2867
E-ISSN
1475-2867
DOI
10.1186/1475-2867-12-11
