Exploratory Review and In Silico Insights into circRNA and RNA-Binding Protein Roles in γ-Globin to...
Exploratory Review and In Silico Insights into circRNA and RNA-Binding Protein Roles in γ-Globin to β-Globin Switching
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Publisher
Switzerland: MDPI AG
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Language
English
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Publisher
Switzerland: MDPI AG
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Contents
β-globin gene cluster regulation involves complex mechanisms to ensure proper expression and function in RBCs. During development, switching occurs as γ-globin is replaced by β-globin. Key regulators, like BCL11A and ZBTB7A, repress γ-globin expression to facilitate this transition with other factors, like KLF1, LSD1, and PGC-1α; these regulators e...
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Full title
Exploratory Review and In Silico Insights into circRNA and RNA-Binding Protein Roles in γ-Globin to β-Globin Switching
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TN_cdi_doaj_primary_oai_doaj_org_article_14d3061f68654875bb13b2a33af4086c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_14d3061f68654875bb13b2a33af4086c
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ISSN
2073-4409
E-ISSN
2073-4409
DOI
10.3390/cells14040312
