HDAC6 modulates myofibril stiffness and diastolic function of the heart
HDAC6 modulates myofibril stiffness and diastolic function of the heart
About this item
Full title
Author / Creator
Lin, Ying-Hsi , Major, Jennifer L , Liebner, Tim , Hourani, Zaynab , Travers, Joshua G , Wennersten, Sara A , Haefner, Korey R , Cavasin, Maria A , Wilson, Cortney E , Jeong, Mark Y , Han, Yu , Gotthardt, Michael , Ferguson, Scott K , Ambardekar, Amrut V , Lam, Maggie Py , Choudhary, Chunaram , Granzier, Henk L , Woulfe, Kathleen C and McKinsey, Timothy A
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Passive stiffness of the heart is determined largely by extracellular matrix and titin, which functions as a molecular spring within sarcomeres. Titin stiffening is associated with the development of diastolic dysfunction (DD), while augmented titin compliance appears to impair systolic performance in dilated cardiomyopathy. We found that myofibril...
Alternative Titles
Full title
HDAC6 modulates myofibril stiffness and diastolic function of the heart
Authors, Artists and Contributors
Author / Creator
Major, Jennifer L
Liebner, Tim
Hourani, Zaynab
Travers, Joshua G
Wennersten, Sara A
Haefner, Korey R
Cavasin, Maria A
Wilson, Cortney E
Jeong, Mark Y
Han, Yu
Gotthardt, Michael
Ferguson, Scott K
Ambardekar, Amrut V
Lam, Maggie Py
Choudhary, Chunaram
Granzier, Henk L
Woulfe, Kathleen C
McKinsey, Timothy A
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_150af97ede814fce977a15aa3d27a1dc
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_150af97ede814fce977a15aa3d27a1dc
Other Identifiers
ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI148333
